Hitchcock Lab


Blood cell production (haematopoiesis) is tightly regulated by a number of different factors to ensure that the numbers of circulating blood cells are maintained within a physiological range. Haematopoietic cytokines and their receptors are essential in regulating blood cell production, and consequently, aberrant haematopoietic cytokine singling can often lead to haematological malignancies or myelodysplatic syndromes. Our lab is interested in the molecular mechanisms of haematopoietic cytokine signalling and how mutations in cytokine receptors and their associated proteins cause haematological disorders and vascular complications in humans.