Regulation of Human Follicular Dendritic Cell Function

We aim to develop an in vitro culture model of the Germinal Centre (GC) reaction using primary human cells allowing B cell – Follicular Dendritic Cell (FDC) interactions permitting analysis of molecular mechanisms controlling CD21L expression and function on human FDCs and provide an in vitro culture system to test potential therapeutic approaches to target B-cell mediated autoimmune disorders.